PIEZO is recommended due to it being less invasive as normal ICSI

Intracytoplasmic sperm injection (ICSI) is a medical advancement in the individuals and couples seeking fertility. It has a wide clinical application and is used in accordance to In Vitro Fertilization (IVF). The goal of assisted reproduction in the case of ICSI is to help those with fertilization failures when few sperm cells are available. However, a new exciting ICSI technology has been approved since the early 1990’s known as PIEZO- ICSI technique by utilizing PIEZO pipettes, which has been trialed and performed in a number of human and other mammalian subjects. PIEZO is recommended due to it being less invasive as normal ICSI. The female’s oocyte is damaged less during penetration. The PIEZO- ICSI technique used ultrasonic measures to cut through the oocyte through two measures, lightly penetrating the zona pellucida with a pulse and then using negative pressure to inject the sperm. There is improved survival rates and satisfaction in those hoping for pregnancy all thanks to the PIEZO method, which we’ll go into detail in this article.


PIEZO is not only effective for ICSI seeking individuals but also safer. How it is implemented is through the idea of a soft and easy penetration. As any ICSI procedure where the oocyte is carefully placed under a microscope and stable platform, injecting the sperm filled pipette is performed. However unlike using a sharp tipped needle in conventional ICSI, the mechanism for PIEZO used a delicate force. PIEZOelectric vibratory movements use an impact force to penetrate the zona pellucida of the oocyte. The zona peculiar isn’t sucked into the pipette or deepened like regular ICSI when perforated. The force from the PIEZO method is one quick swift movement, which allows the sperm to be penetrated with the footswitch control by the pipette driver all while maintaining the oocyte shape. The tip of the pipette is micro in size and also a flat blunt end. This renders is safer and less damaging to the oocyte as well as easier sperm retrieval.


The exact methodology of PIEZO is both electronically and physically executed. The pipette is virtually controlled using a PIEZO PMM4g touchscreen monitoring system. An electronic touch screen can easily control the speed, depth and intensity of the pipette. Once the pipette fully penetrates the zona pellucida, the pipe is retracted a bit and the portion of the penetrated pellucida is expelled. The sperm is then allowed to easily and freely enter the oocyte. The settings are once more adjusted to lessen the speed and rate to prevent any membrane damage. With a quick switch and pule by the pipette, the sperm is then fully penetrated and the needle is retracted.


With the better efficacy and knowledge of PIEZO ICSI vs regular ICSI, the patient now has choices on which method to choose. With regard to safety, PIEZO ICSI causes less deformation of the zona pellucida membrane compared to ICSI. Internal pressure of the oocyte is reduced which increases survival rate and developing embryos. Nevertheless, a stable and successful fertilization is the goal of every couple of individual seeking fertility. Though more costly, the PIEZO ICSI method is promising for improved outcomes and whichever path is chosen is best fit for those longing for pregnancy. Find out more from out fertility centre in Petaling Jaya / KL, Malaysia.

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